Effect of Wogonoside in Streptozotocin Induced Oxidative Stress and Inflammation in Diabetic Rats

Wogonoside is a flavonoid, the main effective constituent of Scutellaria baicalensis , belongs to the Lamiaceae family, with various functions, including detoxification, anti-inflammation and nourishing gallbladder, lowering blood pressure, diuresis and anti-allergic reactions. This study was designed to evaluate the positive role of Wogonoside (WS) on streptozotocin (STZ)-induced diabetes mellitus in rats. Rats were randomized into six groups: Normal control, STZ (60 mg/kg) induced diabetic rats, STZ + WS (100 mg/kg), STZ + WS (200 mg/kg), STZ + Glibenclamide (600 µg/kg) and WS alone (200 mg/kg). After 45 days, the plasma glucose, glycated hemoglobin (HbAC1), insulin level, carbohydrate metabolizing enzyme (Glucokinase, Glucose 6-Phosphatase, Fructose 1,6 -bisphosphatase and Glucose 6-phosphate dehydrogenase), biochemical parameters such as Aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, uric acid, creatinine, total cholesterol, triglycerides, phospholipids, Free fatty acids, Low-density Lipoprotein-C and High-density Lipoprotein-C and antioxidant enzymes status were measured. A pathological condition of the liver, kidney and pancreas was examined by hematoxylin-eosin (H&E) staining. After 45 days of treatment, the results showed that WS had significant antihyperglycemic and total cholesterol-lowering effects and improved serum high-density lipoprotein (HDL) cholesterol levels. WS also enhanced glucose tolerance and the histological state of the liver in diabetic rats and exhibited intriguing antioxidant activities.