Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025The FASEB JournalOpen Access

The Pathophysiological Functions of Heparanases: From Evolution, Structural and Tissue‐Specific Perspectives

View Full Paper
Ask AI
Bookmark
Share

Authors

EVElham VahdataharCDClément DaviaudHMHeather Main

Discussion

Loading...

Member takes

Overview

This review explores the roles of heparanase 1 and heparanase 2 in cancer and immune cells, suggesting distinct contributions in pathophysiology.

Key Points

  • Heparanase 1 cleaves heparan sulfate, impacting cancer processes and immune cell function.
  • The review integrates findings from various mouse models to clarify HPSE1 and HPSE2 contributions in pathologies.
  • Evolutionary analysis reveals relationships between HPSE1 and HPSE2, contrasting their functions and activities.
  • AlphaFold 3 provides structural insights, aiding understanding of the functional molecular determinants distinguishing HPSE1 from HPSE2.

Cite This Study

Vahdatahar et al. (2025) studied this question.

synapsesocial.com/papers/68c187269b7b07f3a06111eahttps://doi.org/10.1096/fj.202501859r
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy2016 · 227 citations
  2. 2Impact of heparanase‐2 (Hpa2) on cancer and inflammation: Advances and paradigms2024 · 8 citations
  3. 3Nuclear localization of heparanase 2 (Hpa2) attenuates breast carcinoma growth and metastasis2024 · 5 citations
  4. 4Expression of the heparan sulfate-degrading enzyme heparanase is induced in infiltrating CD4+ T cells in experimental autoimmune encephalomyelitis and regulated at the level of transcription by early growth response gene2007 · 61 citations
  5. 5Processing of the Human Heparanase Precursor and Evidence That the Active Enzyme Is a Heterodimer1999 · 201 citations