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Observational analysis reveals colocalisation of TTR and medin in the aortic wall, indicating their involvement in amyloidoses.
Background Cross-seeding and co-assembly of multiple amyloid species are increasingly recognised in various organs and amyloidoses. Medin and wild-type transthyretin (TTR) both form age-related amyloid deposits and have been identified within the aortic wall. Given the emerging role of amyloid in aortic disease, this study investigates the potential colocalisation of TTR and medin in the aorta.
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Maerivoet et al. (2025) studied this question.
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