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September 10, 2025Open Access

m6A methylation regulates RNA axonal localisation and translation in developing neurons

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Authors

ARAntonella RiccioBCBraulio Martinez De La CruzMRC Laboratory for Molecular Cell BiologySGSimon GalkinETH Zurich

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Implication

Observational analysis highlights m6A's role in RNA transport in neurons, suggesting implications for axon growth.

Key Points

  • m6A modification critically regulates RNA transport and local translation in developing neurons, impacting growth.
  • Nerve Growth Factor promotes methylated transcript localization, inhibiting premature protein synthesis in axons.
  • Mutation of m6A elements in Trp53Inp2 caused ectopic translation and defects in axon extension and neuronal death.
  • This work emphasizes m6A's importance in RNA localization and spatial protein expression regulation in neurons.

Cite This Study

Riccio et al. (2025) studied this question.

synapsesocial.com/papers/68c187269b7b07f3a06113achttps://doi.org/10.1101/2025.09.01.671701
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