Effects of an Electronic Patient Reported Outcome Measures (e‐PROMs) Program on Symptom Reporting, Use of Healthcare, and Overall Survival in Patients With Lymphoma: A Multicenter Prospective Study

Background Healthcare is shifting from a disease‐centered to patient‐centered approach, and aspects of health such as quality of life (QoL) are becoming increasingly relevant. “E‐Res Salud” for hematological malignancies is a value‐based healthcare program aiming to improve patient experience and outcomes. The program collects e‐PROMs via automatically deployed, validated questionnaires over a mobile application. Methods A multicenter prospective observational cohort study including 243 patients with Hodgkin and non‐Hodgkin lymphoma receiving outpatient intravenous immunochemotherapy at four teaching hospitals in Madrid, Spain, of whom 121 participated in the “E‐Res Salud” program. Results We found that adverse event reporting differs significantly between patients and healthcare professionals. Participants showed significantly lower rates of emergency department visits (37.2% vs. 56.6%; p < 0.01) and unplanned hospital admissions (21.5% vs. 32.8%; p < 0.05), as well as significantly higher rates of treatment completion and overall survival (88.4% vs. 79.5% after 18 months of follow‐up; stratified hazard ratio, 2.30; 95% CI 1.25–4.22; p = 0.007). Conclusions An e‐PROMS program for patients with lymphoma is associated with lower use of healthcare and improved clinical outcomes. Patients and hematologists report adverse events differently, demonstrating the importance of patient‐reported outcome measurement to improve symptom management in clinical practice. Trial Registration : The authors have confirmed clinical trial registration is not needed for this submission