Experiments demonstrated Anoectochilus roxburghii extract suppresses the cGAS-STING pathway in mice, suggesting new therapies for acute lung injury.
Background: Acute lung injury (ALI) is a severe respiratory disorder characterized by systemic immune dysregulation, where hyperactivation of the cGAS-STING pathway contributes to disease progression. Traditional Chinese medicine (TCM) represents a rich source of bioactive compounds that may offer novel therapeutic strategies for targeting this pathway. Objective: This study aimed to evaluate the potential of Anoectochilus roxburghii extract (ARE) as an inhibitor of the cGAS-STING pathway and assess its efficacy in alleviating ALI in experimental models. Methods: The inhibitory effects of ARE on cGAS-STING signaling were examined in bone marrow-derived macrophages (BMDMs) and THP-1 cells. An LPS-induced ALI mouse model was employed to investigate the anti-inflammatory properties of ARE. The therapeutic outcomes of high-dose ARE were compared with those of the STING inhibitor C-176. Results: ARE effectively suppressed cGAS-STING pathway activation without disrupting STING oligomerization. In the ALI model, ARE significantly mitigated lung inflammation, demonstrating comparable efficacy to C-176. Conclusion: These findings suggest that ARE is a promising natural candidate for treating ALI by targeting the cGAS-STING pathway. Its therapeutic potential may extend to other inflammatory diseases associated with cGAS-STING dysregulation.
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Ren et al. (2025) studied this question.
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