Characterization of cytokine secretion and polyfunctionality in patients with systemic autoinflammatory diseases suggests significant immune dysregulation compared to healthy controls.
Dysregulated cytokine secretion and signaling underlie systemic autoinflammatory diseases (SAIDs). Here, we characterized immune dysregulation in SAID patients by profiling cytokine secretion at the single-cell level, establishing measurements for secretion dynamics and cellular polyfunctionality, compared with healthy controls, revealing natural variability within immune responses between donors.
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Linder et al. (2025) studied this question.
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