Omics data reveals that hemophagocytosis, IL-18, and type I IFN distinguish Still disease, suggesting distinct patient subgroups.
This unprecedented large omics dataset of SAIDs, revealed that complex interactions between hemophagocytosis, IL-18 and type I IFN signaling characterize SD. Furthermore, two distinct subgroups in SD patients are distinguished by the degree of hemophagocytic activity. Finally, the large proteomics and RNAseq datasets generated in this study can serve as an invaluable resource for the further investigation SD and other SAIDs.
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Mueller et al. (2026) studied this question.
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