Exploring the Large-scale Regulation of Hydrogen Selenide Release Rate by Selenoanhydride Structures and Their Cytotoxic Effects Toward 4T1 Cells

Yuquan Zou; Xiang Yu; Yumei An; Hanliang He; Jian Yuan; Jiangdong Zhang; Mingyang Zhang; Guoqing Jin; Jiajia Li; Jian‐Xin Zhu; Xiangqiang Pan

doi:10.1039/d5nj02723c

January 1, 2025New Journal of Chemistry

Exploring the Large-scale Regulation of Hydrogen Selenide Release Rate by Selenoanhydride Structures and Their Cytotoxic Effects Toward 4T1 Cells

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Key Points

Hydrogen selenide release demonstrates significant regulation through selenohydride structures, impacting cytotoxicity.
Key evidence shows that altered release rates of hydrogen selenide significantly affect the cytotoxicity toward 4T1 cells.
Observational analysis on selenoanhydride structures indicates their potential to serve as controllable hydrogen selenide donors.
Findings highlight the importance of understanding hydrogen selenide in selenoprotein biosynthesis and cell viability.

Implication

This study demonstrates large-scale regulation of hydrogen selenide release in 4T1 cells, implying potential therapeutic applications.

Abstract

Hydrogen selenide (H2Se) serves as a critical metabolic intermediate in the biosynthesis of selenoproteins. However, its investigation has been impeded by the scarcity of controllable H2Se donors. This study introduces...

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Cite This Study

Zou et al. (2025) studied this question.

synapsesocial.com/papers/68c189e09b7b07f3a0613b70 https://doi.org/10.1039/d5nj02723c

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Exploring the Large-scale Regulation of Hydrogen Selenide Release Rate by Selenoanhydride Structures and Their Cytotoxic Effects Toward 4T1 Cells

Key Points

Implication

Abstract

Discussion

Cite This Study

Exploring the Large-scale Regulation of Hydrogen Selenide Release Rate by Selenoanhydride Structures and Their Cytotoxic Effects Toward 4T1 Cells

Key Points

Implication

Abstract

Discussion

Cite This Study

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