This research demonstrates chemoselective deprotonation of fluoroarenes in microflow using arylpotassium species, suggesting new pathways for functionalization.
We have found the disguised reactivity of Lochmann–Schlosser-type arylpotassium species towards functionalized fluoroarenes in microflow reaction field. Generation of short-lived arylpotassium species in microflow channels and their rapid reactions with cyano- and bromo-fluoroarenes underwent selectivey deprotonation and subsequent functionalization with various electrophiles.
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Okamoto et al. (2025) studied this question.
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