Demonstrates the effectiveness of nitrosonium tetrafluoroborate in α,α-diacetoxylation of aryl methyl ketones, indicating a viable synthetic route.
under mild, metal-free conditions. The reaction exhibits a broad substrate scope, tolerating aryl groups with diverse electronic properties, although slightly electron-deficient substrates afford higher efficiencies. Mechanistic studies support a radical pathway initiated by single-electron-transfer (SET) nitrosation of the enol form of the methyl aryl ketone.
No takes yet. Share an insight, caveat, or question.
Li et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: