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September 10, 2025NutrientsOpen Access

Adaptive Responses in Severe Acute Malnutrition: Endocrinology, Metabolomics, Mortality, and Growth

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This review discusses adaptive mechanisms of severe acute malnutrition, highlighting roles of metabolomics and endocrine factors.

Euglycemia and survival are prioritized in severe acute malnutrition over linear growth due to hormonal regulation.
White adipose tissue plays a crucial role in energy supply, metabolic homeostasis, and immune response in malnourished children.
Clinical recovery from severe acute malnutrition can lead to catch-up growth but may also cause metabolic complications.
Adaptive responses to nutritional deprivation involve complex hormonal interactions that conserve muscle mass and glucose.

Page et al. (2025) studied this question.

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