Ligand-free C-H functionalization using palladium nanocatalyst for the synthesis of 2‑phenylindoles and their anticancer potential

Harini G. Sampatkumar; S. Likitha; Manesh Kumar; Sudhanva M. Srinivasa; C. V. Yelamaggad; Ramesh B. Dateer; Kiran B. Manjappa; Siddappa A. Patil

doi:10.1039/d5tb01178g

January 1, 2025Journal of Materials Chemistry B

Ligand-free C-H functionalization using palladium nanocatalyst for the synthesis of 2‑phenylindoles and their anticancer potential

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Key Points

The ligand-free C-H functionalization achieved high efficiency in synthesizing 2-phenylindoles, enhancing anticancer properties.
Pd@FO-BCN nanocatalyst displays broad functional group tolerance and minimal palladium loading for sustainable synthesis.
This approach utilizes a magnetically separable system, ensuring ease of catalyst recovery and reduced environmental impact.
The findings support the potential of palladium-based nanocatalysts in developing sustainable, effective methods for drug synthesis.

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Implication

Novel palladium nanocatalyst demonstrates effective C-H functionalization and anticancer potential in 2-phenylindole synthesis.

Abstract

We report a sustainable, magnetically separable Pd@FO-BCN nanocatalyst with minimal Pd loading for efficient ligand-free C-H functionalization in 2-phenylindole synthesis. This novel heterogeneous system shows broad functional group tolerance, high...

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Sampatkumar et al. (2025) studied this question.

synapsesocial.com/papers/68c18c019b7b07f3a0614695 https://doi.org/10.1039/d5tb01178g

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Ligand-free C-H functionalization using palladium nanocatalyst for the synthesis of 2‑phenylindoles and their anticancer potential

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Cite This Study

Ligand-free C-H functionalization using palladium nanocatalyst for the synthesis of 2‑phenylindoles and their anticancer potential

Key Points

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Abstract

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