New Pd(allyl)Cl complexes improve reactivity in Suzuki–Miyaura cross-coupling of aryl halides, suggesting potential for advancing catalysis.
This study introduces a new class of (NHC)Pd(allyl)Cl complexes featuring thiazol-2-ylidene ligands, which exhibit enhanced steric and electronic properties compared to those of traditional imidazol-2-ylidenes. These air-stable Pd(II)–NHC catalysts demonstrate superior reactivity in chemoselective Suzuki–Miyaura cross-couplings of aryl bromides and amides. Kinetic studies reveal their superior reactivity over traditional imidazol-2-ylidene-based complexes. The findings highlight the potential of thiazole-based carbenes in advancing Pd-catalyzed cross-coupling reactions.
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Wang et al. (2025) studied this question.
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