Guides for Developing Hundreds of Novel Chiral MXenes and MBenes Nanosheets/Quantum Dots for Next‐Generation Chiral Engineered Biomaterials Applications

The development and multiple bio‐applications of chiral MXene nanosheets and derived quantum dots‐based heterostructures as next‐generation plant biostimulants are recently reported in Small for the first time. This chirality‐induction came at a critical juncture in the field, as the safety efficacy of synthetic low‐dimensional materials, including MXenes, challenges their clinical, agricultural, and environmental translatability. Using a rational surface engineering and structural‐modification strategy, distinct left‐ or right‐handed chiral MXenes are developed. These tailored asymmetric MXenes inherently leverage desirable durability, long‐term biocompatibility, and multifunctional bioactivities. Chirality, as a natural biological specification of living organisms and most bio‐macromolecules, plays a pivotal role in their cellular functions, interactions, enzyme–substrate recognition, protein folding, genetic encoding, and immune‐related mechanisms. Chiral engineering of nanomaterials has set paradigms to open up avenues of studies toward designing numerous novel chiral MXenes and MBenes. Here, this innovative perspective presents a roadmap for periodic development of chiral MXenes/MBenes of diverse chemical compositions and forms. In particular, prospective vacancies and step‐by‐step guides for constructing hundreds of different MXene/MBene formulations are proposed through diverse chiral‐active sources. Induced chirality is anticipated to relatively enhance the properties and biocompatibility of their original materials. It paves the way for extending and optimizing this nano‐biotechnology to more effectively activate, regulate, or control biological responses. These prospects are anticipated to cover antimicrobial coating, immune modulation, tissue engineering, drug delivery, cancer treatments, cell therapies, organ‐transplant rejection prevention, and other healthcare/diagnostic aspects of electrochemically active‐nanomaterials in bio‐tracking, wearable bioelectronics, and biomedical sensors. The basic predictions of their toxicity behaviors across various biological settings are also discussed, and their bio‐properties are speculated on to prioritize design recommendations and strategize the possible chiral‐functionalization challenges.