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September 10, 2025Frontiers in ImmunologyOpen Access

Safety and efficacy of laparoscopic radical gastrectomy after neoadjuvant chemotherapy plus immunotherapy: a retrospective cohort study

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Authors

JXJuan XiongYZYu ZouYZYunlong Zhang

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Overview

Retrospective cohort study shows safety and improved pathologic response in LAGC patients receiving neoadjuvant therapies, suggesting potential benefits without higher risks.

Key Points

  • NACI improved pathologic complete response rates compared to NAC, showing 20.2% versus 12.6%.
  • The rate of R0 resection was significantly higher in the NACI group at 91.3% compared to 84.1%.
  • NACI showed significant declines in ypT0 and ypN0 rates, indicating a positive pathological response.
  • No significant difference in disease-free survival or overall survival between the NACI and NAC groups at 3 years.

Cite This Study

Xiong et al. (2025) studied this question.

synapsesocial.com/papers/68c18c109b7b07f3a0614e17https://doi.org/10.3389/fimmu.2025.1672547
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