Ultra-Low Attachment Surface Enabling 3D Co-Culture of Human B Cells with CD40L-Expressing Stromal Cells for In Vitro Mimicry of Secondary Lymphoid Organs

Ajay Kumar; K. W. Park; Kang Moo Huh; Kyung‐Ho Roh

doi:10.1039/d5bm01039j

January 1, 2025Biomaterials ScienceOpen Access

Ultra-Low Attachment Surface Enabling 3D Co-Culture of Human B Cells with CD40L-Expressing Stromal Cells for In Vitro Mimicry of Secondary Lymphoid Organs

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Key Points

The 3D co-culture system enables B cell proliferation and differentiation in a controlled environment, enhancing in vitro studies.
Significant interactions between B cells and stromal cells were observed, with implications for understanding lymphoid organ dynamics.
This methodology mimics the microenvironment of secondary lymphoid organs, providing insights into immune responses.
Future applications may include disease modeling and drug testing, highlighting the utility of this experimental approach.

Implication

Experimental model demonstrates co-culture of B cells and stromal cells, suggesting new insights into lymphoid organ function.

Abstract

B cells are critical components of the adaptive immune system that proliferate and differentiate within the secondary lymphoid organs upon recognition of antigens and engagement of T cells. Traditional two-dimensional...

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Cite This Study

Kumar et al. (2025) studied this question.

synapsesocial.com/papers/68c18c169b7b07f3a06151e2 https://doi.org/10.1039/d5bm01039j

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Ultra-Low Attachment Surface Enabling 3D Co-Culture of Human B Cells with CD40L-Expressing Stromal Cells for In Vitro Mimicry of Secondary Lymphoid Organs

Key Points

Implication

Abstract

Discussion

Cite This Study

Ultra-Low Attachment Surface Enabling 3D Co-Culture of Human B Cells with CD40L-Expressing Stromal Cells for In Vitro Mimicry of Secondary Lymphoid Organs

Key Points

Implication

Abstract

Discussion

Cite This Study

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