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September 10, 2025Science AdvancesOpen Access

Path integration impairments reveal early cognitive changes in subjective cognitive decline

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Authors

VSVladislava SegenMKM. Humayun KabirASAdam Streck

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Overview

Observational analysis reveals higher path integration errors in subjective cognitive decline participants, indicating early markers for Alzheimer’s disease.

Key Points

  • Path integration deficits may serve as an early marker of neurodegeneration in subjective cognitive decline.
  • SCD participants showed significantly higher path integration error, primarily due to increased memory leak.
  • Immersive virtual reality tasks were used to assess path integration performance in participants.
  • Findings highlight the potential of self-motion navigation tasks for early detection of Alzheimer’s disease.

Cite This Study

Segen et al. (2025) studied this question.

synapsesocial.com/papers/68c18f2a9b7b07f3a0615529https://doi.org/10.1126/sciadv.adw6404
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