Identification of SARS1 as a Prognostic Biomarker in Invasive Lobular Carcinoma Using Lasso-Logistic Regression.

Aminoacyl-tRNA synthetases (ARSs) have emerging roles in cancer biology. Specifically, TARS1 has been linked to immunosuppressive microenvironments and poor prognosis in breast cancer. To identify other ARS genes with prognostic relevance in invasive lobular carcinoma (ILC), we applied lasso-logistic regression to 41 ARS genes using TCGA RNA-seq data and using patient vital status as the binary outcome. Survival analysis showed SARS1 expression was associated with significantly reduced survival across 5 and 10 years, while CARS2 showed significance at 5 years only. These findings support SARS1 as a candidate prognostic biomarker in ILC and suggest broader relevance for ARS genes in breast cancer outcomes.