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September 10, 2025British Journal of DermatologyOpen Access

A national cohort study of melanoma BRAF status, testing patterns, patient and tumour characteristics, treatment and survival in England 2016-21

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Authors

KMKhaylen MistryPJPolly JeffreyNLN. J. Levell

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Overview

National cohort study reveals BRAF testing patterns and survival disparities in melanoma patients, suggesting improvements in treatment access.

Key Points

  • BRAF mutations associated with lower five-year net survival, particularly in stage II melanoma patients.
  • Only 14.4% of newly diagnosed melanomas had BRAF testing registered, indicating significant testing inadequacy.
  • Geographic disparities in BRAF testing rates highlight the need for uniform testing protocols across regions.
  • BRAF mutation rates were influenced by age and gender, with older patients and females less likely to be tested.

Cite This Study

Mistry et al. (2025) studied this question.

synapsesocial.com/papers/68c18f329b7b07f3a06155afhttps://doi.org/10.1093/bjd/ljaf351
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