Generating human primordial germ cell-like cells from pluripotent stem cells: a scoping review of in vitro methods

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This is a Literature Review study.

Madalena Vaz Santos; Ilse de Bruin; Nina Dartée; Mathangi Lakshmipathi; Geert Hamer; C.L. Mulder; Willy M. Baarends; Ans M. M. van Pelt; Susana M. Chuva de Sousa Lopes

doi:10.1093/hropen/hoaf056

September 2, 2025Human Reproduction OpenOpen Access

Generating human primordial germ cell-like cells from pluripotent stem cells: a scoping review of in vitro methods

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Key Points

All analyzed protocols successfully generated primordial germ cell-like cells and showed varying levels of germ cell maturation.
A systematic search revealed 32 articles describing human primordial germ cell-like cell differentiation protocols.
Using 2D or 3D culture systems with specific signaling pathways effectively induced germ cell differentiation outcomes.
The review aids researchers in selecting protocols, but extensive experimental comparisons are needed to improve protocol efficiency.

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Implication

This scoping review compares various in vitro protocols for generating primordial germ cell-like cells, highlighting differentiation outcomes and methodologies.

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Cite This Study

Santos et al. (2025) studied this question.

synapsesocial.com/papers/68c18f329b7b07f3a0615816 https://doi.org/10.1093/hropen/hoaf056

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Generating human primordial germ cell-like cells from pluripotent stem cells: a scoping review of in vitro methods

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Generating human primordial germ cell-like cells from pluripotent stem cells: a scoping review of in vitro methods

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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