Evaluation of the antibiofilm, effects the related mechanisms on colistin-resistant Pseudomonas aeruginosa

Pseudomonas aeruginosa is thought to be the third most frequent cause of catheter-associated UTIs. The production of urease greatly increases the effectiveness of catheter blockage caused by biofilm formation. Because biofilms are important virulence factors that make antibiotics less effective, there is an urgent need to develop novel antibiotic substitutes. Urinary tract infections have been mostly linked to Pseudomonas aeruginosa (P. aeruginosa). The final line of treatment for P. aeruginosa infections is colonistin. But when it comes to treating individuals with colistin-resistant (COL-R) P. aeruginosa, colistin is losing its effectiveness. This study looked into how the antibiofilm, characteristics, and underlying mechanisms of COL-R P. aeruginosa. Our results showed that at (62 μg/ml) sub–Minimum Inhibitory Concentration (MIC), colistin showed remarkable biofilm inhibitory outcome in wild type strains of P. aeruginosa that are multidrug resistant. Strong biofilm producer strains were incubated with 1ml of sub-MIC of colistin for 24 and 48 hours at 37C, the colistin was also examined for their ability to inhibit the biofilm-forming P. aeruginosa. colistin-provide an innovative strategy for biomedical therapy of resistant bacteria because of their elevated antibacterial effect, but only for certain purposes.