Synthesis, Characterization of Novel Heterocyclic Schiff’s Base Derivatives Containing Benzothiazole Rings and study of their anticancer activity

This study focuses on the synthesis, characterization, and anticancer evaluation of novel Schiff base derivatives containing benzothiazole rings. Schiff bases, known for their diverse biological activities, particularly anticancer properties, have modified in this research to enhance their therapeutic potential. The synthesis achieved via the condensation reaction between 2-aminobenzothiazole and various aldehydes, yielding Schiff bases with structural diversity, which characterized by techniques such as Fourier-transform infrared spectroscopy (FT-IR). The incorporation of the benzothiazole moiety into the Schiff base derivatives shown to enhance their biological activity, particularly in terms of anticancer efficacy. Anticancer activity evaluated through MTT assays using human cancer cell lines, including MCF-7 and HeLa. The Schiff base derivatives exhibited dose-dependent cytotoxicity, with the hydroxy-substituted compound demonstrating higher potency compared to the nitro-substituted derivative. Statistica