This research demonstrates enhanced motility and aerotaxis in prostate cancer polyaneuploid cells under hypoxia, suggesting a mechanism for metastasis.
Key Points
PACCs migrated significantly farther than Non-PACCs, indicating greater potential for invasion.
Knockdown of HIF-1α and RhoA reduced PACCs' motility and aerotaxis under hypoxic conditions.
Time-lapse microscopy revealed PACCs exhibited a strong tendency for directed migration towards oxygen.
The findings highlight PACCs as a uniquely invasive cancer cell subpopulation, informing anti-metastatic strategies.