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September 10, 2025Biophysical ReportsOpen Access

Skeletal Muscle Alpha Actin (ACTA1) Acetylation Enhances Myosin Binding and Increases Calcium Sensitivity

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Chemical acetylation of ACTA1 improves myosin binding and calcium sensitivity in skeletal muscle, suggesting physiological implications.

ACTA1 acetylation increased calcium sensitivity, suggesting a functional role in muscle contraction.
High-level acetylation of ACTA1 significantly enhanced myosin binding to actin during muscle contraction.
Acetylation resulted in decreased actin sliding velocity and filament length, indicating altered muscle dynamics.
This study highlights the importance of acetylation as a posttranslational modification affecting skeletal muscle function.

Romanick et al. (2025) studied this question.

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