Peptides from frog skin for wound repair: a systematic review

Skin wounds are common injuries, and many treatments have been proposed, especially membranes. Some studies have been exploring the potential of the skin of Amphibians as a source of peptides for wound treatment, which has been an extremely promising source of bioactives to be used, although there is a lack of effects on pre-clinical animal models, which makes it difficult to understand the results and the choice of the best protocol to use. In this context, the purpose of this study was to perform a systematic review of the literature to examine the effects of membranes manufactured with peptides from frogs on the process of healing skin wounds using in vivo experimental models. This systematic review was carried out based in the orientations of Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) utilizing PubMed, Scopus and Web of Science databases. This review confirms the significant benefits of using these peptides for injury repair and regeneration. Moreover, a faster healing and a full wound closure, with well-organized dermal and epidermal layers were found in the wounds treated peptides from frog skin.