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September 10, 2025Frontiers in PsychiatryOpen Access

Changes in psychopathology and peripheral inflammation in schizophrenia patients initiating treatment with second-generation antipsychotics: a post-hoc analysis

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Authors

MHMichel HeilMEMonika EdlingerFBFalko Biedermann

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Overview

Post-hoc analysis examines associations between inflammatory markers and schizophrenia severity, suggesting no link.

Key Points

  • Significant reductions in PANSS (sub)scores were observed over time in patients on second-generation antipsychotics.
  • No changes in inflammatory markers such as CRP, NLR, MLR, and SII were measured during the study period.
  • Linear mixed-effects models indicated no significant associations between psychopathology and inflammation markers.
  • Results suggest that peripheral inflammatory markers do not reliably indicate disease severity in schizophrenia.

Cite This Study

Heil et al. (2025) studied this question.

synapsesocial.com/papers/68c192459b7b07f3a06164e9https://doi.org/10.3389/fpsyt.2025.1644428
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