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September 10, 2025VaccinesOpen Access

Cross-Neutralization of Distant Coronaviruses Strongly Correlates with Spike S2-Specific Antibodies from Immunocompetent and Immunocompromised Vaccinated SARS-CoV-2-Infected Patients

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Authors

SPS. Patel BLBrooke M. Leeman PBPatricia J. Botros

Discussion

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Overview

Analysis reveals that s2-specific antibody levels correlate with neutralization in vaccinated, immunocompromised patients, suggesting implications for broader protection.

Key Points

S2-specific antibodies correlated strongly with neutralization against distant coronaviruses, enhancing potential immunity.
In vaccinated patients, Omicron-S1 antibodies surpassed Wuhan-S1, highlighting variant-specific responses to immunogens.
S2 antibodies were lower than S1 but showed better neutralization correlation, indicating the need for S2-based vaccines.
Findings support the use of S2 immunogens to potentially improve protection for immunocompromised and vulnerable groups.

Cite This Study

Patel et al. (2025) studied this question.

synapsesocial.com/papers/68c1924e9b7b07f3a0616aed https://doi.org/10.3390/vaccines13090949

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September 10, 2025VaccinesOpen Access

Cross-Neutralization of Distant Coronaviruses Strongly Correlates with Spike S2-Specific Antibodies from Immunocompetent and Immunocompromised Vaccinated SARS-CoV-2-Infected Patients

View Full Paper

Ask AI

Bookmark

Authors

SPS. Patel BLBrooke M. Leeman PBPatricia J. Botros

Discussion

Member takes

Overview

Analysis reveals that s2-specific antibody levels correlate with neutralization in vaccinated, immunocompromised patients, suggesting implications for broader protection.

Key Points

S2-specific antibodies correlated strongly with neutralization against distant coronaviruses, enhancing potential immunity.
In vaccinated patients, Omicron-S1 antibodies surpassed Wuhan-S1, highlighting variant-specific responses to immunogens.
S2 antibodies were lower than S1 but showed better neutralization correlation, indicating the need for S2-based vaccines.
Findings support the use of S2 immunogens to potentially improve protection for immunocompromised and vulnerable groups.

Cite This Study

Patel et al. (2025) studied this question.

synapsesocial.com/papers/68c1924e9b7b07f3a0616aed https://doi.org/10.3390/vaccines13090949

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