High-throughput multimodal optofluidic biophysical imaging cytometry

T.R. Lee; Evelyn H. Y. Cheung; Kelvin C. M. Lee; Dickson M. D. Siu; Michelle C. K. Lo; Edmund Y. Lam; Ruchi Goswami; Salvatore Girardo; Kyoohyun Kim; Felix Reichel; Markéta Kubánková; Martin Kräter; Jochen Guck; Kevin K. Tsia

doi:10.1039/d5lc00381d

January 1, 2025Lab on a Chip

High-throughput multimodal optofluidic biophysical imaging cytometry

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Key Points

QP-MORE cytometry achieves over 10,000 cells per second, capturing extensive data rapidly.
The technique provides insights into biophysical and mechanical properties of single cells, enhancing characterization.
This method employs a multimodal approach to analyze various cellular phenotypes effectively and efficiently.
Potential applications include improving diagnostics and therapeutic monitoring by analyzing cell behavior.

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Abstract

Quantitative phase morpho-rheological (QP-MORE) cytometry simultaneously captures a collection of high-resolution biophysical and mechanical phenotypes of single cells at ultrahigh throughput (>10 000 cells per s).

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Lee et al. (2025) studied this question.

synapsesocial.com/papers/68c1924e9b7b07f3a0616b27 https://doi.org/10.1039/d5lc00381d

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High-throughput multimodal optofluidic biophysical imaging cytometry

Key Points

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Abstract

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High-throughput multimodal optofluidic biophysical imaging cytometry

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Abstract

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