Enantioselective 1,4-addition yields high enantioenriched products from azadienes and indolizines, suggesting novel applications.
Herein, we describe an enantioselective 1,4-addition of benzofuran-derived azadienes with indolizines under the catalysis of chiral phosphoric acid, which afforded new enantioenriched triarylmethane products in generally good yields (up to 90%) with high enantioselectivities (up to 98% ee). This method enabled the precise synthesis of enantioenriched triarylmethane products, which are notable for their intricate structures and the presence of two (hetero)aryls.
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Deng et al. (2025) studied this question.
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