Histological study reveals Spondias mombin protects against ibuprofen's ovarian toxicity, suggesting a preventive role.
The ovaries play a crucial role in female reproductive health, but exposure to nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen has been linked to ovarian dysfunction. Consequently, the objective of this paper is a histological investigation of the effects of Spondias mombin ethanol leaf extract on ibuprofen-induced ovarian toxicity in wistar rats using appropriate standard methods. Histological examination revealed normal ovarian architecture in the control and Spondias mombin-only groups, with well-preserved follicles and vascularized stroma. In contrast, the ibuprofen-only group exhibited stromal congestion, vasodilation, and follicular degeneration, indicating significant ovarian toxicity. Co-administration of Spondias mombin with ibuprofen mitigated these effects, preserving ovarian integrity. Pre-treatment with Spondias mombin demonstrated the most protective effect, with a higher number of viable follicles and reduced ovarian damage. However, post-treatment with Spondias mombin was less effective, showing persistent signs of cellular stress and follicular atresia. In conclusion, Spondias mombin exhibits protective effects against ibuprofen-induced ovarian toxicity, particularly when administered prophylactically.
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Ogeyemhe et al. (2025) studied this question.
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