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September 10, 2025Cancer Causes & ControlOpen Access

Molecular mechanisms of bone metastasis in breast cancer based on transcriptomic and microbiomic analysis

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Bone metastasis in breast cancer shows significant gene expression differences, indicating unique molecular pathways involved.
Key genes like IBSP and IDO1 were notably upregulated in BM patients compared to non-bone metastasis cases.
A multi-omics approach included transcriptomic and microbiomic analysis to uncover underlying biological mechanisms.
The study identifies HPV infection pathways and distinct microbiome profiles that may serve as biomarkers for early detection.

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This analysis reveals gene expression and microbiome differences in bone metastasis, highlighting HPV's role as a potential therapeutic target.

Zhang et al. (2025) studied this question.

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This analysis reveals gene expression and microbiome differences in bone metastasis, highlighting HPV's role as a potential therapeutic target.