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September 10, 2025Journal of PancreatologyOpen Access

Role of CAR-T Cell Therapy in Pancreatic cancer: An Updated Narrative Review of Current Evidence.

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CAR-T cell therapy shows promise for pancreatic cancer, addressing treatment resistance and poor survival rates.
Early clinical trials targeting specific tumor antigens like mesothelin indicate potential effectiveness against PDAC.
Research highlights challenges in T-cell persistence and immune evasion that limit the efficacy of CAR-T therapy.
Innovative engineering of CAR-T cells aims to enhance their ability to target and treat solid tumors effectively.

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Narrative review assesses CAR-T therapy in pancreatic cancer, highlighting challenges and potential improvements.

Bejjani et al. (2025) studied this question.

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