Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Open Access

Sirtuin 1 Activation Mitigates Murine Vasculitis Severity by Promoting Autophagy and Mitophagy

View Full Paper
Ask AI
Bookmark
Share

Authors

AAAsli E. AticiPJPrasant Kumar JenaTCThacyana T. Carvalho

Discussion

Loading...

Member takes

Overview

Examination of Sirtuin 1's impact on vasculitis severity in mice, highlighting autophagy and inflammation pathways.

Key Points

  • SIRT1 overexpression significantly reduced severe vasculitis in a murine model of Kawasaki disease.
  • NAD+ precursor supplementation restored SIRT1 levels and improved autophagy, reducing pro-inflammatory cytokine production.
  • Specific deletion of Sirt1 in vascular smooth muscle cells and myeloid cells worsened vasculitis severity.
  • The impaired NAD+-SIRT1 axis suggests therapeutic potential for targeting inflammation in Kawasaki disease.

Cite This Study

Atici et al. (2025) studied this question.

synapsesocial.com/papers/68c192579b7b07f3a0616f35https://doi.org/10.1101/2025.09.04.671113
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 1117: Il-1 Signaling On Vascular Smooth Muscle Cells Accelerates Atherosclerosis After Murine Kawasaki Disease Vasculitis2024
  2. 2Sirtuin 1 deficiency mediates chronic kidney disease-induced inflammaging cardiovascular calcification2026
  3. 3Interleukin-1β Is Crucial for the Induction of Coronary Artery Inflammation in a Mouse Model of Kawasaki Disease2012 · 250 citations
  4. 4Progression of vascular function and blood pressure in a mouse model of Kawasaki disease2022 · 2 citations
  5. 5Sirtuin 1 Inhibition Attenuates Viral Myocarditis by Suppressing the Nuclear Translocation of Pyruvate Kinase M2 to Rebalance Th17/Th9 Differentiation2026