Cobalt-Catalyzed Direct Carbonylative 3-Acylation of (N-H)Indoles with Alkyl Halides

Chao Xu; Zhipeng Bao; Sufang Shao; Xiao‐Feng Wu

doi:10.1039/d5sc05810d

January 1, 2025Chemical ScienceOpen Access

Cobalt-Catalyzed Direct Carbonylative 3-Acylation of (N-H)Indoles with Alkyl Halides

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Key Points

This method allows effective carbonylative acylation of indoles, expanding synthetic utility.
The transformation enhances C-H functionalization using cobalt catalysts with high selectivity.
Intermolecular reactions were successfully achieved using various alkyl halides in the procedure.
Overall, this approach provides a novel strategy for utilizing heterocycles in organic synthesis.

Implication

This process enables C-H acylation of heterocycles with alkyl halides, suggesting efficient transformations.

Abstract

A cobalt-catalyzed approach to intermolecular carbonylative 3-acylation of heterocycles via C-H functionalization is described. This transformation enables the direct C-H acylation of indoles and pyrroles with alkyl halides. Notably, this...

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Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/68c1925e9b7b07f3a0617218 https://doi.org/10.1039/d5sc05810d

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Cobalt-Catalyzed Direct Carbonylative 3-Acylation of (N-H)Indoles with Alkyl Halides

Key Points

Implication

Abstract

Discussion

Cite This Study

Cobalt-Catalyzed Direct Carbonylative 3-Acylation of (N-H)Indoles with Alkyl Halides

Key Points

Implication

Abstract

Discussion

Cite This Study

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