Research demonstrates bioresorption and antibacterial activity of sodium alginate-based composites, suggesting potential in reconstructive surgery.
Porous composite materials with a matrix of a blend of polyvinylpyrrolidone (PVP) and sodium alginate (ALG) polymers, in which ceramic particles of double (manganese- and strontium)-substituted tricalcium phosphate (TCP) are distributed, have been developed. The XRD method showed that the main crystalline phase of (manganese- and strontium)-substituted TCP is whitlockite. As a result of in vitro studies, it was revealed that all the studied materials are not adhesive to cells and do not have a cytotoxic or inhibitory effect on them. Porous composite materials with a high rate of bioresorption of ceramic particles and a high potential for antibacterial activity and osteoinductive properties due to ion diffusion and changes in the properties of the surface layer can be used in reconstructive surgery to restore bone tissue function.
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Фадеева et al. (2025) studied this question.
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