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September 10, 2025MedComm – Future MedicineOpen Access

Circulating Tumor Cell‐Derived Organoids: Current Progress, Applications, and Future

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Review highlights CTC-derived organoids' applications in tumor precision medicine and identifies challenges, suggesting areas for future development.

CTC-derived organoids retain tumor heterogeneity and metastatic potential, enhancing research potential.
Current strategies for CTC isolation face challenges such as low success rates and technical difficulties.
Research largely focuses on single cancer types, limiting broader applicability across various tumors.
Standardization in the construction and application of CTC-derived organoids is necessary for advancing precision therapy.

Li et al. (2025) studied this question.

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Review highlights CTC-derived organoids' applications in tumor precision medicine and identifies challenges, suggesting areas for future development.