Giant Pleomorphic Adenoma of the Nasal Septum: A Case Report and Review of Diagnostic and Surgical Considerations

Introduction: Pleomorphic adenoma is the most common benign tumor of the salivary glands, typically arising in the major salivary glands but occasionally found in minor salivary glands within the oral cavity. Its occurrence in the nasal cavity is exceptionally rare and may mimic more common nasal lesions, posing a diagnostic challenge. Case Presentation: We report the case of a patient presenting with progressive unilateral nasal obstruction. Endoscopic examination revealed a polypoid mass in the nasal cavity, and imaging studies were performed to assess its extension. Complete surgical excision was carried out via a combined approach. Histopathological analysis confirmed the diagnosis of pleomorphic adenoma originating from the minor salivary glands of the nasal cavity. Conclusion: Although extremely rare, pleomorphic adenoma of the nasal cavity should be considered in the differential diagnosis of nasal masses. Early diagnosis and complete surgical excision are essential for favorable outcomes. This report aims to highlight the diagnostic and surgical challenges associated with this unusual presentation in light of current literature.