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Assessment reveals enhanced tumor uptake and binding affinity in hypoxic conditions, suggesting improved imaging potential.
A peptide-based, hypoxia-inducible factor-1 α (HIF-1α) specific PET tracer for tumor hypoxia imaging is reported. It was prepared with a rapid Al18F labeling method with high stability. Al18F-CLLFVY specifically binds to HIF-1α with high affinity and shows higher uptake in cells under hypoxia. Al18F-CLLFVY demonstrated comparable tumor uptake to 18F-FMISO and better contrast.
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Chen et al. (2025) studied this question.
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