Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025NeuropsychopharmacologyOpen Access

Disentangling the effects of corticotrophin releasing factor and GABA release from the bed nucleus of the stria terminalis on ethanol self-administration in mice

View Full Paper
Ask AI
Bookmark
Share

Authors

CGCarol A. GianessiHHHarold L. HaunDPDipanwita Pati

Discussion

Loading...

Member takes

Overview

Operant self-administration reveals how corticotrophin releasing factor and GABA influence ethanol intake in male and female mice, suggesting distinct roles for each molecule.

Key Points

  • CRF deletion in BNST neurons reduces ethanol intake in both male and female mice, indicating strong sex-dependent effects.
  • Suppression of GABA release leads to increased ethanol self-administration and decreased motivation for sucrose, showing distinct regulatory roles.
  • The study utilized viral vectors to separate CRF and GABA effects on ethanol consumption in a controlled operant self-administration environment.
  • Findings suggest that BNST CRF release is crucial for intense ethanol drinking behaviors leading to dependence, while GABA affects motivation.

Cite This Study

Gianessi et al. (2025) studied this question.

synapsesocial.com/papers/68c193e99b7b07f3a0617cefhttps://doi.org/10.1038/s41386-025-02192-2
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inhibiting CRF Projections from the Central Amygdala to Lateral Hypothalamus and Amygdala Deletion of CRF Alters Binge-Like Ethanol Drinking in a Sex-Dependent Manner2024 · 1 citations
  2. 2Dopamine D2 receptors in the bed nucleus of the stria terminalis modulate alcohol-related behaviors2024 · 3 citations
  3. 3Mouse parasubthalamic Crh neurons drive alcohol drinking escalation and behavioral disinhibition2024 · 4 citations
  4. 4<scp>BNST G</scp>lu<scp>N</scp>2<scp>D</scp>‐containing <scp>NMDAR</scp>s contribute to ethanol intake but not negative affective behaviors in female mice2024 · 2 citations
  5. 5Alcohol attenuates CRF-induced excitatory effects from the extended amygdala to dorsostriatal cholinergic interneurons2026