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Enantioselective Incorporation of Amine Fragments onto Quaternary Carbons via Metallaphotoredox Catalysis

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Metallaphotoredox platform enables asymmetric coupling of amines to quaternary carbons, revealing new synthetic possibilities.

Exceptional enantioselectivity is achieved in the construction of quaternary carbon stereocenters with amine functionalities.
The method allows the incorporation of amine fragments onto quaternary carbons via coupling with α-silylamines.
Photocatalysis enables the generation of α-amino alkyl radicals for enantioselective coupling without harsh reagents.
This platform shows broad functional group tolerance, expanding access to diverse drug-like molecules.

Zu et al. (2025) studied this question.

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