In silico and in vitro Antimicrobial Assessment of Oroxylum indicum (L). Kurz stem bark extract against four Bacterial and Fungal Species

In the present study, we used oroxylum indicum (OI) a traditional medicinal plant stem bark extract to evaluate its antimicrobial and anti-inflammatory properties. The antibacterial and antifungal properties of Oroxylum indicum stem bark extract were assessed by well diffusion assay. Further, the anti-inflammatory property of OI stem bark extract was evaluated using egg albumin denaturation and bovine serum albumin denaturation assays. The cytotoxicity was evaluated by MTT assay. The OI extract showed antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli exhibiting the maximum zone of inhibition. From the results of antifungal activity, it was evident that the OI stem bark extract showed maximum zone of inhibition against the test organisms namely, Aspergillus niger, Aspergillus flavus, Aspergillus fumigatus and Penicillium citricus. From our study findings, it is evident that OI stem bark extract has the potential to be used for treating bacterial and fungal infection.