This cascade converts alcohols to enantioenriched amines using alcohol oxidase and reductive amination, highlighting effective biocatalysis.
We report a one-pot biocatalytic cascade for the conversion of allylic alcohols into enantioenriched secondary amines through a sequence involving oxidation followed by conjugate reduction–reductive amination (CR–RA). This transformation, catalyzed by cholesterol oxidase (ShCO) and an ene-imine reductase (EneIRED), proceeds under mild conditions and accommodates a broad substrate scope. In several cases, the cascade outperforms the stepwise method and exhibits substrate-dependent selectivity, highlighting the advantages of tandem enzymatic systems for efficient and streamlined chiral amine synthesis.
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Miletic et al. (2025) studied this question.
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