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September 10, 2025Open Access

Thymidylate synthase inhibitory drugs induce p53-dependent pathways differently

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This analysis reveals distinct transcriptional effects of drugs 5FdUR and RTX on p53 in cancer cells, suggesting unique regulatory mechanisms.

Distinct transcriptional signatures were observed following inhibition of thymidylate synthase by both drugs.
Both 5FdUR and raltitrexed triggered DNA damage responses alongside S-phase arrest in colon cancer cells.
TS inhibition disrupts dUTP:dTTP balance, leading to cell death through various RNA-level regulatory networks.
Transcriptomic analyses highlighted the multifaceted impact of thymidylate synthase inhibition on post-transcriptional regulation.

Békési et al. (2025) studied this question.

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This analysis reveals distinct transcriptional effects of drugs 5FdUR and RTX on p53 in cancer cells, suggesting unique regulatory mechanisms.