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The Presence, Origins and Potential Role of Bi-hormonal Endocrine Cells Within the Pancreatic Islets of Langerhans

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Bi-hormonal endocrine cell populations persist and change in relation to age, impacting potential roles in glucose regulation.
Age-related analysis shows glucagon/insulin cell counts increase while other bi-hormonal combinations decrease significantly.
Pancreatic development reveals that improper timing in stem cell lineage can lead to the formation of bi-hormonal cells, detectable via transcriptomic methods.
The findings indicate that bi-hormonal cells can respond adaptively under metabolic stress, proposing avenues for diabetes treatment.

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This research examines bi-hormonal cells' origins and roles in pancreatic islets, suggesting potential therapeutic applications.

David Hill (2025) studied this question.

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