Study demonstrates how tgf-β crosstalk with hgf and egf affects liver progenitor cell proliferation, suggesting potential therapeutic avenues in liver failure.
Background and Aims: Liver progenitor cells (LPCs) performing vital liver function can rescue patients with acute liver failure (ALF) from death. To date, key signaling controlling LPC proliferation and initiating liver functional gene expression remains largely unknown. This study investigates the crosstalk between TGF-β and HGF/EGF signaling in LPC proliferation and performing liver functional gene transcription.
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Tong et al. (2025) studied this question.
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