Cohort study associates NUCKS1 levels with aggressivity in PDAC, suggesting its role as a prognosis marker.
Introduction: The ductal adenocarcinoma of the pancreas (PDAC) is an aggressive form of cancer that remains difficult to manage despite intensive research. NUCKS1 (nuclear casein kinase and cyclin dependent kinase substrate1) is a protein present in almost all human cells with an important role in proliferation and DNA repair, demonstrated to have correlated with aggressivity and prognosis in many types of cancer.
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Bobe et al. (2025) studied this question.
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