Transitional type circulating tumor cells predict systemic recurrence and benefit of adjuvant chemotherapy after resection of pancreatic ductal adenocarcinoma: long-term outcomes of the CLUSTER trial

Ingmar F. Rompen; Joseph R. Habib; A. Marchetti; Elisabetta Sereni; Jin He; B. Hewitt; Gordon S. Sacks; Katherine M. Morgan; Awais Javed; Christopher L. Wolfgang

doi:10.1055/s-0045-1810952

September 1, 2025Zeitschrift für Gastroenterologie

Transitional type circulating tumor cells predict systemic recurrence and benefit of adjuvant chemotherapy after resection of pancreatic ductal adenocarcinoma: long-term outcomes of the CLUSTER trial

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Key Points

Transitional circulating tumor cells effectively predict systemic recurrence after pancreatic cancer surgery.
Findings suggest that patients with identified circulating tumor cells may benefit from adjuvant chemotherapy.
The CLUSTER trial provides long-term outcome data supporting the role of circulating tumor cells in treatment decisions.
This analysis underscores the importance of evaluating circulating tumor cells for personalized cancer therapy.

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Implication

Observational analysis shows transitional circulating tumor cells predict systemic recurrence in pancreatic cancer, indicating potential adjuvant chemotherapy benefits.

Abstract

Aim: To evaluate the role of transitional circulating tumor cells (trCTCs) in predicting systemic recurrence and survival benefit from adjuvant chemotherapy.

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Rompen et al. (2025) studied this question.

synapsesocial.com/papers/68c194029b7b07f3a06186e5 https://doi.org/10.1055/s-0045-1810952

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Transitional type circulating tumor cells predict systemic recurrence and benefit of adjuvant chemotherapy after resection of pancreatic ductal adenocarcinoma: long-term outcomes of the CLUSTER trial

Key Points

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Implication

Abstract

Discussion

Cite This Study

Transitional type circulating tumor cells predict systemic recurrence and benefit of adjuvant chemotherapy after resection of pancreatic ductal adenocarcinoma: long-term outcomes of the CLUSTER trial

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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