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September 1, 2025Zeitschrift für Gastroenterologie

Efficacy of xyloglucan, pea protein and chia seed powder for patients with constipation-predominant irritable bowel syndrome: a randomised placebo-controlled trial

S Bradic Waqar Malik J. Wray Kin Ki Tai S. Casella G Bramati B Karnani

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Key Points

Results indicate xyloglucan may alleviate symptoms of constipation in IBS-C patients, improving quality of life.
The study observed significant symptom reduction with xyloglucan, with patients reporting relief from discomfort and bloating.
A randomised placebo-controlled trial assessed effects of xyloglucan and pea protein on bowel function in adults with IBS-C.
These findings suggest dietary supplementation may benefit IBS-C patients, highlighting the need for further exploration.

Implication

Randomised trial tested xyloglucan and pea protein for gut health in patients with IBS-C, suggesting potential benefits.

Abstract

Background: Irritable bowel syndrome with constipation (IBS-C) is a complex functional gastrointestinal disorder.

Discussion

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Cite This Study

Bradic et al. (2025) studied this question.

synapsesocial.com/papers/68c194029b7b07f3a06186e9 https://doi.org/10.1055/s-0045-1810694

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Acacia fiber or probiotic supplements to relieve gastrointestinal complaints in patients with constipation-predominant IBS: a 4-week randomized double-blinded placebo-controlled intervention trial2024 · 14 citations
2Efficacy and safety of Xyloglucan (XG), pea protein and tannins (PPT), and Xylo-oligosaccharides (XOS) for diarrhoea-predominant irritable bowel syndrome: a randomised, crossover clinical trial2025
3Chitin-glucan improves important pathophysiological features of irritable bowel syndrome2024 · 7 citations
4Therapeutic Effects of Chrysin in an Ice-water-induced Rat Model of Constipation-predominant Irritable Bowel Syndrome (IBS-C)Original Research · 2026
5The Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols Diet Is Effective in Irritable Bowel Syndrome With Constipation: A Single Center Tertiary Care Clinical Practice EvaluationOriginal Research · 2026