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Analysis highlights metallothionein's potential as a diagnostic marker for Wilson disease, suggesting improved accuracy in identifying copper metabolism disorders.
Aims: Wilson disease (WD) is a genetic disorder of copper metabolism caused by mutations in the ATP7B gene. Toxic copper accumulation leads to hepatic, neurologic, and psychiatric disorders with variable presentation. Metallothionein (MT) immunohistochemistry was proposed as a diagnostic marker.
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Mohr et al. (2025) studied this question.
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